Arbitrados

• Achievements, Challenges, and Scope of Thirty Years of Work on the Biotransformation of Arenes and Their Synthetic Applications (Completo, 2022)

  SCHAPIRO, V. , BROVETTO, M , CARRERA, I. , GAMENARA, D , DAVID GONZÁLEZ , PANDOLFI, E. , SEOANE, G.
  Asian Journal of Organic Chemistry, v.: 11 12 , 2022
  Areas de conocimiento:
  Ciencias Naturales y Exactas / Ciencias Químicas / Química Orgánica / Biocatálisis
  Medio de divulgación: Internet
  E-ISSN: 21935815
  DOI: 10.1002/ajoc.202200530
  http://dx.doi.org/10.1002/ajoc.202200530
  
  

• Synthesis of Azido Dienediols by Enzymatic Dioxygenation of Benzylazides: An Experimental and Theoretical Study (Completo, 2022)

  VICTORIA SOVERA , SEBASTIÁN MARTÍNEZ , DIEGO UMPIÉRREZ , MARÍA AGUSTINA VILA , DAVID GONZALEZ , GUSTAVO SEOANE , NICOLÁS VEIGA , IGNACIO CARRERA
  European Journal of Organic Chemistry, v.: 2022 5 , 2022
  Palabras clave: toluene dioxygenase Azido-Dienediols computational chemistry
  Medio de divulgación: Internet
  Lugar de publicación: United kingdom
  ISSN: 1434193X
  E-ISSN: 10990690
  DOI: 10.1002/ejoc.202101156
  http://dx.doi.org/10.1002/ejoc.202101156
  
  

• Advice on assistance and protection provided by the Scientific Advisory Board of the Organisation for the Prohibition of Chemical Weapons: Part 3. On medical care and treatment of injuries from sulfur mustard (Completo, 2021)

  CHRISTOPHER M. TIMPERLEY , JONATHAN E. FORMAN , MOHAMMAD ABDOLLAHI , ABDULLAH SAEED AL-AMRI , AUGUSTIN BAULIG , DJAFER BENACHOUR , VERONICA BORRETT , FLERIDA A. CARIÑO , CHRISTOPHE CURTY , MICHAEL GEIST , DAVID GONZALEZ , WILLIAM KANE , ZRINKA KOVARIK , ROBERTO MARTÍNEZ-ÁLVAREZ , NICIA MARIA FUSARO MOURÃO , SLAWOMIR NEFFE , SYED K. RAZA , VALENTIN RUBAYLO , ALEJANDRA GRACIELA SUÁREZ , KOJI TAKEUCHI , CHENG TANG , FERRUCCIO TRIFIRÒ , FRANCOIS MAURITZ VAN STRATEN , PAULA S. VANNINEN , SLAVICA VU?INI? , VOLODYMYR ZAITSEV , MUHAMMAD ZAFAR-UZ-ZAMAN , MONGIA SAÏD ZINA , STIAN HOLEN , WESAM S. ALWAN , VIVEK SURI , PETER J. HOTCHKISS , MOSTAFA GHANEI
  Toxicology, v.: 463 p.:152967 2021
  Palabras clave: Chemical warfare agent Blister agent Sulfur mustard Medical management
  Medio de divulgación: Internet
  Lugar de publicación: Netherlands
  ISSN: 0300483X
  DOI: 10.1016/j.tox.2021.152967
  http://dx.doi.org/10.1016/j.tox.2021.152967
  
  

• Purification, structural elucidation, antioxidant capacity and neuroprotective potential of the main polyphenolic compounds contained in Achyrocline satureioides (Lam) D.C. (Compositae) (Completo, 2019)

  MARTINEZ-BUSI M , Florencia Arredondo , GONZALEZ, D. , C. ECHEVERRY , Mauricio A. Vega-Teijido , D. CARVALHO , Rodriguez, A. , RIVERA, F , DAJAS, F. , JUAN ANDRES ABIN-CARRIQUIRY
  Bioorganic & Medicinal Chemistry, v.: 27 12 , p.:2579 - 2591, 2019
  Palabras clave: Flavonoids Neuroprotection Achyrocline satureioides HOMO-LUMO Fukui
  Areas de conocimiento:
  Ciencias Naturales y Exactas / Ciencias Químicas / Química Analítica /
  Medio de divulgación: Internet
  ISSN: 09680896
  E-ISSN: 14643391
  DOI: https://doi.org/10.1016/j.bmc.2019.03.047
  https://www.sciencedirect.com/science/article/pii/S0968089619301300?via%3Dihub
  Achyrocline satureioides (Lam) D.C (Compositae) is a native medicinal plant of South America traditionally utilized for its anti-inflammatory, sedative and anti-atherosclerotic properties among others. Neuroprotective effects have been reported in vivo and could be associated to its elevated content of flavonoid aglycones. In the present study we performed the isolation and structure elucidation of the major individual flavonoids of A. satureioides along with the in vitro characterization of their individual antioxidant and neuroprotective properties in order to see their putative relevance for treating neurodegeneration.
  
  

• Advice on assistance and protection from the Scientific Advisory Board of the Organisation for the Prohibition of Chemical Weapons: Part 2. On preventing and treating health effects from acute, prolonged, and repeated nerve agent exposure, and the identification of medical countermeasures able to reduce or eliminate the longer term health effects of nerve agents (Completo, 2019)

  Christopher M.Timperley , MohammadAbdollahi , Abdullah SaeedAl-Amri , Augustin Baulig , Djafer Benachour , VeronicaBorrett , Flerida A.Cariño , GONZALEZ, D. , Michael Geist , William Kane , 20 autores mas de diversos paises
  Toxicology, v.: 413 p.:13 - 23, 2019
  Palabras clave: Chemical weapon
  Areas de conocimiento:
  Ciencias Naturales y Exactas / Ciencias Químicas / Ciencias Químicas /
  Medio de divulgación: Internet
  ISSN: 0300483X
  DOI: https://doi.org/10.1016/j.tox.2018.11.009
  https://www.sciencedirect.com/science/article/pii/S0300483X18306218?via%3Dihub
  Trabajo de revisión realizado en forma colectiva en la OPCW.
  
  

• Advice on assistance and protection provided by the Scientific Advisory Board of the Organisation for the Prohibition of Chemical Weapons: Part 1. On medical care and treatment of injuries from nerve agents (Completo, 2019)

  Timperley, C.M. Forman, J.E. Abdollahi, M. Al-Amri, A.S. Baulig, A. Benachour, D. Borrett, V. Cariño , GONZALEZ, D.
  Toxicology, v.: 415 p.:56 - 69, 2019
  Palabras clave: chemical weapons
  Areas de conocimiento:
  Ciencias Naturales y Exactas / Ciencias Químicas / Ciencias Químicas /
  Medio de divulgación: Internet
  ISSN: 0300483X
  DOI: 10.1016/j.tox.2019.01.004
  Revisión realizada en forma colectiva en la OPCW
  
  

• Chemoenzymatic Synthesis of Hygromycin Aminocyclitol Moiety and its C2 Epimer (Completo, 2019)Trabajo relevante

  CARRAU, G. , BELLOMO, A. , SUESCUN, L , GONZALEZ, D.
  European Journal of Organic Chemistry, v.: 2019 4 , p.:788 - 802, 2019
  Palabras clave: Cyclitols Biocatalysis Amino alcohols Dihydroxylation Asymmetric synthesis
  Areas de conocimiento:
  Ciencias Naturales y Exactas / Ciencias Químicas / Química Orgánica / Síntesis orgánica
  Medio de divulgación: Internet
  ISSN: 1434193X
  E-ISSN: 10990690
  DOI: 10.1002/ejoc.201801424
  https://onlinelibrary.wiley.com/doi/abs/10.1002/ejoc.201801424
  This manuscript describes the enantioselective synthesis of the aminocyclitol moiety of the antibiotic hygromycin A in eight steps and 39?% overall yield from a non?chiral starting material. The sequence made use of an initial enzymatic step to transfer chirality to an aromatic ring and was followed by selective organic chemistry transformations (oxidation, protection, azidation, hydrolysis) of the six?membered ring in order to achieve the target. The approach is also amenable to the synthesis of other related unnatural analogues as exemplified by the synthesis of the C2 epimer of the natural aminocyclitol. All the intermediates were fully characterized, and the absolute stereochemistry assigned by spectrometric methods.
  
  

• Endophytic biocatalysts with enoate reductase activity isolated from Mentha pulegium. (Completo, 2018)

  MARCONI, F. , UMPIÉRREZ, M. , GONZALEZ, D. , RODRÍGUEZ, S. , RODRÍGUEZ, P.
  World Journal of Microbiology and Biotechnology, v.: 34 4 , p.:50 2018
  Palabras clave: biotransformation enoate reductase endophytic bacteria carvone
  Areas de conocimiento:
  Ciencias Naturales y Exactas / Ciencias Biológicas / Otros Tópicos Biológicos / Biocatálisis
  Medio de divulgación: Internet
  Lugar de publicación: Springer Netherlands
  ISSN: 09593993
  E-ISSN: 15730972
  DOI: 10.1007/s11274-018-2434-7
  https://link.springer.com/article/10.1007%2Fs11274-018-2434-7
  The biotransformation of (4R)-(- )-carvone by Mentha pulegium (pennyroyal) leaves and its endophytic bacteria was performed in order to search for novel biocatalysts with enoate reductase activity. The obtained results clearly indicate that endophytes play an important role in the biotransformation of (4R)-(- )-carvone with pennyroyal plant tissues. The best activity was associated to the endophytic bacteria Pseudomonas proteolytica FM18Mci1 and Bacillus pumilus FM18civ1. Enoate reductase activity for the reduction of (4R)-(- )-carvone and (4S)-(+)- carvone as model substrates was evaluated for each strain. Finally, both isolated strains were evaluated for the kinetic resolution of racemic carvone. The two bacteria gave (1R, 4R) or (1R, 4S)?dihydrocarvone as major products. P. proteolytica FM18Mci1 has preference for the 4S-(- )-carvone, reaching a conversion ?99% in 24 hours. In contrast B. pumilus FM18civ1 has preference for (4R)-(- )-carvone. The results obtained in the kinetic resolution of carvone indicate that the Bacillus strain might be useful for resolving a racemic mixture of carvone.
  
  

• Advice from the Scientific Advisory Board of the Organisation for the Prohibition of Chemical Weapons on riot control agents in connection to the Chemical Weapons Convention (Completo, 2018)Trabajo relevante

  Christopher Timperley , Jonathan Forman , Pal Aas , Mohammad Abdollahi , Djafer Bonachou , Augustin Baulig , Renate Becker-Arnold , Veronica Borrett , Flerida A. Cariño , Christophe Curty , Gonzalez, D. , Michael Geist , William Kane , Zrinka Kovarik , Roberto Martínez-Álvarez , Robert Mikulak , Nicia Maria Fusaro Mourão , Slawomir Neffe , Evandro De Souza Nogueira , Ponnadurai Ramasami , Syed K. Raza , Valentin Rubaylo , Ahmed E. M. Saeed , Koji Takeuchi , Cheng Tang , Ferruccio Trifirò , Francois Mauritz van Straten , Alejandra G. Suárez , Farhat Waqar , Paula S. Vanninen , Mohammad Zafar-Uz-Zaman , Slavica Vu?ini? , Volodymyr Zaitsev , Mongia Saïd Zina , Stian Holen , Fauzia Nurul Izzati
  RSC Advances, v.: 8 p.:41731 - 41739, 2018
  Palabras clave: Chemical weapons Riot control agents OPCW
  Areas de conocimiento:
  Ciencias Naturales y Exactas / Ciencias Químicas / Ciencias Químicas /
  Medio de divulgación: Internet
  Lugar de publicación: Londres
  E-ISSN: 20462069
  DOI: 10.1039/C8RA08273A
  https://pubs.rsc.org/en/content/articlelanding/2018/RA/C8RA08273A#!divAbstract
  Compounds that cause powerful sensory irritation to humans were reviewed by the Scientific Advisory Board (SAB) of the Organisation for the Prohibition of Chemical Weapons (OPCW) in response to requests in 2014 and 2017 by the OPCW Director-General to advise which riot control agents (RCAs) might be subject to declaration under the Chemical Weapons Convention (the ?Convention?). The chemical and toxicological properties of 60 chemicals identified from a survey by the OPCW of RCAs that had been researched or were available for purchase, and additional chemicals recognised by the SAB as having potential RCA applications, were considered. Only 17 of the 60 chemicals met the definition of a RCA under the Convention. These findings were provided to the States Parties of the Convention to inform the implementation of obligations pertaining to RCAs under this international chemical disarmament and non-proliferation treaty.
  
  

• Advice from the Scientific Advisory Board of the Organisation for the Prohibition of Chemical Weapons on isotopically labelled chemicals and stereoisomers in relation to the Chemical Weapons Convention. (Completo, 2018)

  Christopher M. Timperley , Jonathan E. Forman , Mohammad Abdollahi , Abdullah Saeed Al-Amri , Isel Pascual Alonso , Augustin Baulig , Veronica Borrett , Flerida A. Cariño , Christophe Curty , GONZALEZ, D. , Zrinka Kovarik , Roberto Martínez-Alvarez , Robert Mikulak , Nicia Maria Fusaro Mourão , Ponnadurai Ramasami , Slawomir Neffe , Syed K. Raza , Valentin Rubaylo , Koji Takeuchi , Cheng Tang , Ferruccio Trifirò , Francois Mauritz van Straten , Paula S. Vanninen , Volodymyr Zaitsev , Farhat Waqar , Mongia Saïd Zina , Hope A. Weinstein
  Pure and Applied Chemistry, p.:1647 - 1670, 2018
  Areas de conocimiento:
  Ciencias Naturales y Exactas / Ciencias Químicas / Química Analítica /
  Ciencias Naturales y Exactas / Ciencias Químicas / Ciencias Químicas /
  Ciencias Naturales y Exactas / Ciencias Químicas / Ciencias Químicas /
  Medio de divulgación: Internet
  Escrito por invitación
  ISSN: 00334545
  E-ISSN: 13653075
  DOI: 10.1515/pac-2018-0803
  The Chemical Weapons Convention (CWC) is an international disarmament treaty that prohibits the development, stockpiling and use of chemical weapons. This treaty has 193 States Parties (nations for which the treaty is binding) and entered into force in 1997. The CWC contains schedules of chemicals that have been associated with chemical warfare programmes. These scheduled chemicals must be declared by the States that possess them and are subject to verification by the Organisation for the Prohibition of Chemical Weapons (OPCW, the implementing body of the CWC). Isotopically labelled and stereoisomeric variants of the scheduled chemicals have presented ambiguities for interpretation of the requirements of treaty implementation, and advice was sought from the OPCW?s Scientific Advisory Board (SAB) in 2016. The SAB recommended that isotopically labelled compounds or stereoisomers related to the parent compound specified in a schedule should be interpreted as belonging to the same schedule. This advice should benefit scientists and diplomats from the CWC?s State Parties to help ensure a consistent approach to their declarations of scheduled chemicals (which in turn supports both the correctness and completeness of declarations under the CWC). Herein, isotopically labelled and stereoisomeric variants of CWC-scheduled chemicals are reviewed, and the impact of the SAB advice in influencing a change to national licensing in one of the State Parties is discussed. This outcome, an update to national licensing governing compliance to an international treaty, serves as an example of the effectiveness of science diplomacy within an international disarmament treaty.
  
  

• Innovative technologies for chemical security (Reseña, 2018)

  Jonathan E. Forman , Christopher M. Timperley , Pål Aas , Mohammad Abdollahi , Isel Pascual Alonso , Augustin Baulig , Renate Becker-Arnold , Veronica Borrett , Flerida A. Cariño , Christophe Curty , GONZALEZ, D. , Zrinka Kovarik , Roberto Martínez-Álvarez , Robert Mikulak , Evandro de Souza Nogueria , Ponnadurai Ramasami , Syed K. Raza , Ahmed E. M. Saeed , Koji Takeuchi , Cheng Tang , Ferruccio Trifirò , Francois Mauritz van Straten , Farhat Waqar , Volodymyr Zaitsev , Mongia Saïd Zina , Katarína Grolmusová , Guy Valente , Marlene Payva , Siqing Sun , Siqing Sun , Amy Yang , Darcy van Eerten
  Pure and Applied Chemistry, v.: 90 10 , p.:1527 - 1557, 2018
  Areas de conocimiento:
  Ciencias Naturales y Exactas / Ciencias Químicas / Ciencias Químicas /
  Ciencias Naturales y Exactas / Ciencias Químicas / Ciencias Químicas /
  Ciencias Naturales y Exactas / Ciencias Químicas / Ciencias Químicas /
  Medio de divulgación: Internet
  Escrito por invitación
  ISSN: 00334545
  E-ISSN: 13653075
  DOI: 10.1515/pac-2018-0908
  https://www.degruyter.com/view/j/pac.2018.90.issue-10/pac-2018-0908/pac-2018-0908.xml
  Abstract Advances across the chemical and biological (life) sciences are increasingly enabled by ideas and tools from sectors outside these disciplines, with information and communication technologies playing a key role across 21st century scientific development. In the face of rapid technological change, the Organisation for the Prohibition of Chemical Weapons (OPCW), the implementing body of the Chemical Weapons Convention (?the Convention?), seeks technological opportunities to strengthen capabilities in the field of chemical disarmament. The OPCW Scientific Advisory Board (SAB) in its review of developments in science and technology examined the potential uses of emerging technologies for the implementation of the Convention at a workshop entitled ?Innovative Technologies for Chemical Security?, held from 3 to 5 July 2017, in Rio de Janeiro, Brazil. The event, organized in cooperation with the International Union of Pure and Applied Chemistry (IUPAC), the National Academies of Science, Engineering and Medicine of the United States of America, the Brazilian Academy of Sciences, and the Brazilian Chemical Society, was attended by 45 scientists and engineers from 22 countries. Their insights into the use of innovative technological tools and how they might benefit chemical disarmament and non-proliferation informed the SAB?s report on developments in science and technology for the Fourth Review Conference of the Convention (to be held in November 2018), and are described herein, as are recommendations that the SAB submitted to the OPCW Director-General and the States Parties of the Convention. It is concluded that technologies exist or are under development that could be used for investigations, contingency, assistance and protection, reducing risks to inspectors, and enhancing sampling and analysis.
  
  

• Advice on chemical weapons sample stability and storage provided by the Scientific Advisory Board of the Organisation for the Prohibition of Chemical Weapons to increase investigative capabilities worldwide. (Completo, 2018)

  Timperley, C. , Jonathan E. Forman , Mohammad Abdollahi , Abdullah Saeed Al-Amri , Augustin Baulig , Veronica Borrett , Flerida A. Cariño , Christophe Curty , GONZALEZ, D. , Zrinka Kovarik , Roberto Martínez-Álvarez , Robert Mikulak , Nicia Maria Fusaro Mourão , Ramasami Ponnadurai , Slawomir Neffe , Syed K. Raza , Valentin Rubaylo , Koji Takeuchi , Cheng Tang , Ferruccio Trifirò , Francois Mauritz van Straten , Paula S. Vanninen , Volodymyr Zaitsev , Farhat Waqar , Mongia Saïd Zina , Marc-Michael Blum , Hugh Gregg , Elena Fischer , Siqing Sun , Pei Yang
  Talanta, v.: 188 p.:808 - 832, 2018
  Palabras clave: Chemical Weapons OPCW SAB
  Areas de conocimiento:
  Ciencias Naturales y Exactas / Ciencias Químicas / Química Analítica /
  Ciencias Naturales y Exactas / Ciencias Químicas / Ciencias Químicas /
  Medio de divulgación: Internet
  Escrito por invitación
  ISSN: 00399140
  DOI: 10.1016/j.talanta.2018.04.022
  https://www.sciencedirect.com/science/article/pii/S0039914018303680
  Highlights The Scientific Advisory Board (SAB) of the Organisation for the Prohibition of Chemical Weapons (OPCW) considered the long-term storage and stability of samples collected in the context of chemical weapons investigations. The resulting advice, useful for all laboratories that conduct analysis on samples containing chemical warfare agents, their precursors and/or degradation products, is described. The scientific literature on environmental and biomedical sample analysis, and the main degradation products for chemicals on the Schedules in the Annex on Chemicals of the Chemical Weapons Convention, is reviewed. Ten recommendations to ensure the long-term storage and stability of samples collected in relation to the potential use of chemical weapons are provided.
  
  

• Chemoenzymatic synthesis of triazololactams structurally related to pancratistatin (Completo, 2017)Trabajo relevante

  DE LA SOVERA, V. , SUESCUN, L. , BELLOMO, A. , GONZALEZ, D.
  European Journal of Organic Chemistry, v.: 2017 27 , p.:3912 - 3916, 2017
  Palabras clave: click chemistry Alkaloids Asymmetric synthesis Cycloaddition
  Areas de conocimiento:
  Ciencias Naturales y Exactas / Ciencias Químicas / Química Orgánica / Sintesis Organica
  ISSN: 1434193X
  E-ISSN: 10990690
  DOI: 10.1002/ejoc.201700334
  https://onlinelibrary.wiley.com/doi/abs/10.1002/ejoc.201700334
  ABSTRACT Four tricyclic lactams that structurally resemble alkaloids with the pancratistatin skeleton were synthetized from bromobenzene by a chemoenzymatic strategy. The sequence involved enzymatic dihydroxylation, efficient stereodirected oxidation of double bonds, inter- or intramolecular Hüisgen cycloaddition and a solvent free cyclization. The complex structures were obtained in high chemical and optical purity and can be good candidates for biological testing. SELECCIONADO PARA ARTICULO DE TAPA
  
  

• Diels-Alder Reaction of Levoglucosenone with a Protected cis-Cyclohexadienediol: Structural and Electronic Basis behind the Unexpected Stereoselectivity (Completo, 2017)

  MARTíNEZ, S. , CARRAU, G. , GONZALEZ, D. , VEIGA, N.
  ChemistrySelect, v.: 2 34 , p.:11223 - 11230, 2017
  Palabras clave: Diels-Alder levoglucosenone green chemistry
  E-ISSN: 23656549
  DOI: 10.1002/slct.201702442
  http://onlinelibrary.wiley.com/doi/10.1002/slct.201702442/abstract
  Recently, we found that the Diels-Alder reaction between levoglucosenone and the acetonide of (1S,2R)-3-methylcyclohexa-3,5-diene-1,2-diol occurs through the most hindered face of the diene. This unexpected facial selectivity has no precedent for di-O-isopropylidene-protected dienes, and the reasons behind it remain unclear. Here, we expand on our earlier findings, computationally assessing the structural and electronic factors responsible for this unforeseen stereoselectivity. The B3LYP/6-31+G(d,p) results identify the three main adducts (β-endo-ortho:α-endo-meta:α-exo-ortho), giving a product ratio (63:9:28) that is in line with the experimental value (64:16:10). The β-endo attack allows to maximize the electrostatic attraction between the reactants, giving rise to dipolar C−O⋅⋅⋅H−C interactions with the isopropylidene group at the transition state. The endo/exo preference can be rationalized through electrostatic repulsion and steric hindrance between the isopropylidene and methylene fragments. Finally, the non-classical C=O⋅⋅⋅H−C hydrogen bonding stabilizes the ortho transition structures, making them more polar and asynchronous.
  
  

• Novel chemoenzymatic synthesis of an enantiopure allo-inosamine hexaacetate from benzyl azide (Completo, 2016)

  DE LA SOVERA, V. , GARAY, P. , THEVENET, N. , MACíAS, M. A. , GONZALEZ, D. , SEOANE, G , CARRERA, I.
  Tetrahedron Letters, v.: 57 23 , p.:2484 - 2487, 2016
  Palabras clave: Aminocyclitol Allylic Azide Aminoccis-Cyclohexadienediols
  Areas de conocimiento:
  Ciencias Naturales y Exactas / Ciencias Químicas / Química Orgánica / Sintesis Organica
  Medio de divulgación: Internet
  Lugar de publicación: Oxford
  E-ISSN: 00404039
  DOI: 10.1016/j.tetlet.2016.04.072
  http://www.sciencedirect.com/science/article/pii/S0040403916304464
  A facile and short chemoenzymatic synthesis of (-) 1L-5-amino-5-deoxy-allo-inositol hexaacetate is described using benzyl azide as starting material. The key transformations consist of an enzymatic dioxygenation using the toluene dioxygenase enzymatic complex, followed by an allylic azide double sigmatropic [3,3] shift to introduce the nitrogen functionality in the ring in a stereoselective manner. Azide reduction and further regioselective oxidation of the diene moiety afforded the desired inosamine in only eight steps from benzyl azide.
  
  

• Diels-Alder reaction of two green chiral precursors. Approach to natural product like structures. (Completo, 2016)

  CARRAU, G. , VEIGA, N. , SUESCUN, L. , GIRI, G. F. , SUAREZ, A. , SPANEVELLO, R. , GONZALEZ, D.
  Tetrahedron Letters, v.: 57 p.:4791 - 4794, 2016
  Palabras clave: Diels-Alder Quimca verde
  Areas de conocimiento:
  Ciencias Naturales y Exactas / Ciencias Químicas / Química Orgánica /
  Medio de divulgación: Internet
  E-ISSN: 00404039
  DOI: 10.1016/j.tetlet.2016.09.031
  http://www.sciencedirect.com/science/article/pii/S0040403916311881
  
  

• Endophytic microorganisms: A source of potentially useful biocatalysts (Completo, 2016)

  RODRIGUEZ, P. , GONZALEZ, D. , RODRíGUEZ, S.
  Journal of Molecular Catalysis B Enzymatic, v.: 133 1 , 2016
  Escrito por invitación
  ISSN: 13811177
  DOI: 10.1016/j.molcatb.2017.02.013
  http://www.sciencedirect.com/science/article/pii/S1381117717300322
  Abstract One of the major challenges in biocatalysis is the discovery or development of novel biocatalysts suitable for different applications. Within the last decades, directed evolution has emerged as a powerful tool for generating diversity and has allowed the development of biocatalysts with the desired properties. An alternative way to increase diversity among biocatalysts is to further explore nature on the search for novel activities or broader substrate specificity. Recent estimations indicate that we have been able to culture in the lab only 1% of the existing microorganisms, thus the strategy of searching for enzyme activities among existing microorganisms could still provide a manifold of useful biocatalysts. The endophytic community is a particularly interesting group of microorganisms since they have adapted themselves to live in an environment rich in biologically active compounds. Furthermore, several endophytes are able to produce secondary metabolites mimicking their host plant. It has been proposed that the endophytes have acquired these capabilities through years of co-evolution with their host plant. These characteristics indicate that endophytic microorganisms can be a rich source of novel enzymes; despite that, they have been scarcely explored in biocatalysis. This review attempts to cover all the precedents in the area of biotransformation and biocatalysis mediated by endophytic microorganisms.
  
  

• Double [3,3]-Sigmatropic Rearrangement in the Enzymatic Dioxygenation of Benzyl Azide: Preparation of Novel Synthetically Valuable Azido-diols. (Completo, 2015)

  THEVENET, N. , DE LA SOVERA, V. , VILA, A. , VEIGA, N. , GONZALEZ, D. , SEOANE, G , CARRERA, I.
  Organic Letters, v.: 17 p.:684 - 687, 2015
  Palabras clave: sigmatropic rearrangement
  Areas de conocimiento:
  Ciencias Naturales y Exactas / Ciencias Químicas / Química Orgánica / Sintesis Organica
  Ciencias Naturales y Exactas / Ciencias Químicas / Química Orgánica / Biocatalisis
  Medio de divulgación: Internet
  Lugar de publicación: USA
  ISSN: 15237060
  E-ISSN: 15237052
  DOI: 10.1021/ol503708v
  http://pubs.acs.org/doi/abs/10.1021/ol503708v
  Enzymatic dioxygenation of benzyl azide by toluene dioxygenase produces the expected enantiopure cis-cyclohexadienediol along with an exocyclic diene formed by a spontaneous sequence of two [3,3] sigmatropic shifts. This novel dienediol presents high synthetic potential for natural product synthesis. The sigmatropic rearrangements can be reversed by protection of the diol moiety. An optimized production protocol for either of these valuable diols is presented. Ignacio Carrera es el autor corresponsal del artículo.
  
  

• Greener Synthesis of an Amide by Direct Reaction of an Acid and Amine under Catalytic Conditions (Completo, 2015)

  ARCE, G. , CARRAU, G. , BELLOMO, A. , GONZALEZ, D.
  World Journal of Chemical Education, v.: 3 1 , p.:27 - 29, 2015
  Palabras clave: química verde
  Areas de conocimiento:
  Ciencias Naturales y Exactas / Ciencias Químicas / Química Orgánica / Quimica Verde
  Ciencias Naturales y Exactas / Ciencias Químicas / Química Orgánica / Educacion
  Medio de divulgación: Internet
  ISSN: 23751665
  DOI: 10.12691/wjce-3-1-4
  http://pubs.sciepub.com/wjce/3/1/4/index.html
  A simple and high-yielding laboratory experiment that involves the boric acid catalyzed amidation of benzoic acid is described. The experiment makes use of recent chemistry, it is appropriate for advanced undergraduate chemistry students, and demonstrates several important concepts including homogeneous catalysis and green chemistry.
  
  

• 3-Hydroxycineole bioproduction from 1,8-cineole using Gymnopilus spectabilis 7423 under resting cell conditions (Completo, 2015)

  VEGA, B. , REYES, B. , RODRIGUEZ, P. , SIERRA, W. , GONZALEZ, D. , MENENDEZ, P.
  Biocatalysis, v.: 1 1 , p.:44 - 48, 2015
  Palabras clave: Biocatalysis cineole
  Areas de conocimiento:
  Ciencias Naturales y Exactas / Ciencias Químicas / Química Orgánica / Biocatalisis
  Medio de divulgación: Internet
  Lugar de publicación: Alemania
  ISSN: 08864454
  DOI: 10.1515/boca-2015-0002
  http://www.degruyter.com/view/j/boca.2014.1.issue-1/boca-2015-0002/boca-2015-0002.xml?format=INT
  Abstract: This report describes the high yield biotransformation of 1,8-cineole by the strain Gymnopilus spectabilis 7423, a common fungus isolated from the Eucalyptus tree. The biotransformation was conducted under resting cell conditions and different parameters were tested in order to achieve up to 90% bioconversion. Only two regioisomers were detected, and they were identified as 3-α-hydroxy-1,8-cineole and 2-α-hydroxy-1,8- cineole obtained in a 82:8 ratio.
  
  

• A study of Raphanus sativus and its endophytes as carbonyl group bioreducing agents (Completo, 2015)

  RODRIGUEZ, P. , MAGALLANES-NOGUERA, C. , MENENDEZ, P. , ORDEN, A. A. , GONZALEZ, D. , KURINA-SANZ, M. , RODRíGUEZ, S.
  Biocatalysis and Biotransformation, v.: XX 2015
  Palabras clave: Biocatalysis
  Areas de conocimiento:
  Ciencias Naturales y Exactas / Ciencias Químicas / Química Orgánica / Biocatalisis
  Medio de divulgación: Internet
  ISSN: 10242422
  E-ISSN: 10292446
  DOI: 10.3109/10242422.2015.1053471
  http://informahealthcare.com/doi/abs/10.3109/10242422.2015.1053471
  The reported anti-Prelog selectivity in Raphanus sativus hairy roots prompted us to search for similar activity in other R. sativus systems, such as in vitro germinated sprouts, edible roots, and its associated endophytic microorganisms. Two test substrates were used in these studies: acetophenone and rac-ethyl 2-ethyl-3-oxobutanoate. Endophytes were isolated under substrate selective pressure and individual strains were evaluated for their ability to reduce both substrates. Among the isolates, two bacteria and a fungus having the potential to be used as biocatalysts were found: Bacillus megaterium which reduces acetophenone with excellent anti-Prelog selectivity, and Pseudomonas sp. and Penicillium chrysogenum with enantioselectivity and stereoselectivity for the reduction of rac-ethyl 2-ethyl-3-oxobutanoate, respectively.
  
  

• Chemoenzymatic synthesis of fluoxetine precursors. Reduction of Beta-substituted propiophenones. (Completo, 2014)

  CORONEL, C. , ARCE, G. , IGLESIAS, C. , MAGALLANES NOGUERA, C. , RODRIGUEZ BONNECARRÈRE, P. , RODRÍGUEZ GIORDANO, S. , GONZALEZ, D.
  Journal of Molecular Catalysis B Enzymatic, v.: 102 p.:94 - 98, 2014
  Areas de conocimiento:
  Ciencias Naturales y Exactas / Ciencias Químicas / Química Orgánica / Biocatalisis
  Medio de divulgación: Internet
  ISSN: 13811177
  DOI: 10.1016/j.molcatb.2014.01.022
  http://dx.doi.org/10.1016/j.molcatb.2014.01.022
  Abstract: Five endophytic yeast strains isolated from edible plants were tested in the reduction B-chloro- and B-azidopropiophenone for the preparation of optically active fluoxetine precursors. The biotransformation rendered not only the corresponding chiral γ-substituted alcohols, but also unsubstituted alcohols and ketones. The product profile was studied and a plausible mechanism for the reductive elimination of the β-functional group is proposed.
  
  

• Antifungal Activity of a Library of Cyclitols and Related Compounds (Completo, 2013)

  BERTUCCI, A. , BELLOMO, A. , DE LA SOVERA, V. , CARRAU, G. , RAIMONDI, M. , SACCHINO, S. , STEFANI, H. A. , GONZALEZ, D.
  Letters in Drug Design & Discovery, v.: 11 1 , p.:67 - 75, 2013
  Areas de conocimiento:
  Ciencias Naturales y Exactas / Ciencias Químicas / Química Orgánica /
  Medio de divulgación: Internet
  ISSN: 15701808
  DOI: 10.2174/15701808113109990036
  http://eurekaselect.com/112749
  Abstract: The antifungal activity of a library of 32 cyclitols and derivatives, including 6 previously unreported cyclitol amino acid conjugates, was studied against the clinically important yeasts Candida albicans, Candida tropicalis and Cryptococcus neoformans along with Saccharomyces cerevisiae. Bioautography followed by standardized microbroth dilution methods were used and allowed to identify an azidoinositol glycoside (11) and an azidoconduritol linked to an aromatic aldehyde (18) as promising compounds. The results suggest the relevance of exploring synthetic cyclitolic structures as potential antifungal leaders.
  
  

• Synthesis and preliminary biological evaluation of a compound library of triazolylcyclitols (Completo, 2013)

  CARRAU, G. , DREWES, CARINE C , SHIMADA, A. , BERTUCCI, A. , FARSKY, SANDRA H. , STEFANI, H. A. , GONZALEZ, D.
  Bioorganic & Medicinal Chemistry, v.: 21 p.:4225 - 4232, 2013
  Areas de conocimiento:
  Ciencias Naturales y Exactas / Ciencias Químicas / Química Orgánica /
  Medio de divulgación: Internet
  ISSN: 09680896
  E-ISSN: 14643391
  DOI: 10.1016/j.bmc.2013.04.084
  http://dx.doi.org/10.1016/j.bmc.2013.04.084
  Abstract: A small library of compounds was prepared by a combination of toluene dioxygenase (TDO)-catalyzed enzymatic dihydroxylation and copper (I)-catalyzed Hüisgen cycloaddition. Some compounds were obtained by coupling an alkyne and a conduritol derivative, while more complex structures were obtained by a double Hüisgen reaction of a dialkyne and two molecules of the cyclitol. The compounds were fully characterized and subjected to preliminary biological screening.
  
  

• Synthesis and Field Evaluation of Synthetic Blends of the Sex Pheromone of Crocidosema aporema (Lepidoptera: Tortricidae) in Soybean (Completo, 2012)

  GONZALEZ, A. , ALTESOR, P , ALVEZ, L. , LIBERATTI, P. , SILVA, H. , RAMOS, J. C. , CARRERA, I. , GONZALEZ, D. , SEOANE, G , ROSSINI, C. , CASTIGLIONI, E. , GAMENARA, D.
  Journal of the Brazilian Chemical Society, v.: 23 p.:1997 - 2002, 2012
  Areas de conocimiento:
  Ciencias Naturales y Exactas / Ciencias Químicas / Química Orgánica /
  Medio de divulgación: Internet
  Lugar de publicación: Brasil
  E-ISSN: 01035053
  http://www.jbcs.sbq.org.br/imagebank/pdf/v23n11a06.pdf
  Abstract: Crocidosema (= Epinotia) aporema (Walsingham) (Lepidoptera: Tortricidae) is a bud borer that feeds on soybean and forage legumes. Its economic importance is restricted to South America, where it can alternate throughout the year between forage and grain legumes. The sex pheromone of C. aporema females is composed of a 15:1 mixture of (7Z,9Z)-dodeca-7,9-dien-1-ol and (7Z,9Z)-dodeca-7,9-dienyl acetate. Aiming at the development of a monitoring tool, it was synthesized both components of the pheromone and evaluated male captures in pheromone traps baited with different blends of synthetic pheromone, in an experimental soybean field in Uruguay. The conjugated dienes were obtained from 2-pentyn-1-ol and 1,7-heptanediol, by oxidation of the former, Wittig coupling and Zn-catalyzed reduction of the triple bond. The 1:1 mixture was the most efficient in capturing males. The pheromone traps were attractive for up to 40 days, even with small septum loads (0.1 mg) and low population levels.
  
  

• Click chemistry and biocatalysis for the preparation of pancratistatin analogs. (Completo, 2011)Trabajo relevante

  DE LA SOVERA, V. , BELLOMO, A. , GONZALEZ, D.
  Tetrahedron Letters, v.: 52 p.:430 - 433, 2011
  Areas de conocimiento:
  Ciencias Naturales y Exactas / Ciencias Químicas / Química Orgánica /
  Medio de divulgación: Internet
  E-ISSN: 00404039
  DOI: 10.1016/j.tetlet.2010.11.084
  http://www.sciencedirect.com/science/article/pii/S0040403910020940
  Abstract: Tricyclic compounds that are advanced precursors for the synthesis of analogs of the antitumoral alkaloid pancratistatin were prepared by a short sequence that involved enzymatic dihydroxylation, epoxidation, and intramolecular Huisgen cycloaddition.
  
  

• Stereoselective biotransformation of α-alkyl-β-keto esters by endophytic bacteria and yeast. (Completo, 2011)

  RODRIGUEZ BONNECARRÈRE, P. , REYES, B. , BARTON, M. , CORONEL, C. , MENENDEZ, P. , GONZALEZ, D. , RODRÍGUEZ GIORDANO, S.
  Journal of Molecular Catalysis B Enzymatic, v.: 71 3-4 , p.:90 - 94, 2011
  Areas de conocimiento:
  Ciencias Naturales y Exactas / Ciencias Químicas / Química Orgánica /
  Medio de divulgación: Internet
  ISSN: 13811177
  DOI: 10.1016/j.molcatb.2011.04.003
  http://www.sciencedirect.com/science/article/pii/S138111771100107X
  Abstract: Several strains of endophytic bacteria and yeast were isolated from Daucus carota, Erythrina crista-galli, Curcubita maxima and Fortunella margarita, and tested for the reduction of two model α-alkyl-β-ketoesters. The yeasts strains resulted better biocatalysts for the reduction of the tested substrates with the exception of E. agglomerans C8 strain, isolated from Erythrina crista-galli, that provided the best results for the preparation of syn (2R,3S) α–alkyl β-hydroxyesters. Among the isolated yeast strains, the Pichia sp strain isolated from Daucus carota, was the best biocatalyst for production of anti (2S,3S) α–alkyl β-hydroxyesters. Our results show that the microbial endophytic community provides an interesting niche on the search for novel biocatalysts.
  
  

• Obtención enzimática de jabón: una revisión verde para un experimento clásico de educación secundaria. (Completo, 2011)

  CASULLO, P. , MENENDEZ, P. , GONZALEZ, D.
  Anuario Latinoamericano de Educación Química, v.: 26 p.:115 - 118, 2011
  Areas de conocimiento:
  Ciencias Naturales y Exactas / Ciencias Químicas / Química Orgánica / Educacion
  Medio de divulgación: Internet
  Lugar de publicación: San Luis, Argentina
  ISSN: 0328087X
  https://www.researchgate.net/publication/261020197_Obtencin_enzimtica_de_jabn_una_revisin_verde_para
  Abstract: La obtención de jabón mediante la hidrólisis de grasa o aceite con hidróxido de sodio, empleando etanol para favorecer la interacción entre el aceite y el agua y cloruro de sodio para precipitar el jabón y separar el glicerol, es una actividad industrial muy antigua y un experimento de laboratorio de amplio uso en Educación Secundaria. En este trabajó se propone una alternativa que incorpora elementos de Química Verde para dicho proceso: la obtención de jabón mediante la hidrólisis de aceite de girasol enriquecido en ácido oleico por la acción de una lipasa, seguida de un tratamiento con carbonato de sodio y cloruro de sodio a temperatura ambiente.
  
  

• Expanding Cyclitol Structural Diversity by Biocatalysis and Metalocatalysis. A Click Chemistry Approach. (Completo, 2011)

  DE LA SOVERA, V. , BELLOMO, A. , GONZALEZ, D. , STEFANI, H. A.
  Molecular Diversity, v.: 15 1 , p.:163 - 172, 2011
  Areas de conocimiento:
  Ciencias Naturales y Exactas / Ciencias Químicas / Química Orgánica /
  Medio de divulgación: Internet
  ISSN: 13811991
  E-ISSN: 1573501X
  DOI: 10.1007/s11030-010-9237-6
  http://dx.doi.org/10.1007/s11030-010-9237-6
  Abstract: The palladium catalyzed cross-coupling reaction of phenyltrifluoroborate with a chemoenzymatically derived bromoazidoconduritol, combined with 1,3-dipolar cycloaddition, with a variety of alkynes is described. Fourteen new compounds were synthesized in moderate to good yields. The click chemistry reaction can be effected by using sodium ascorbate and CuSO4 · 5H2O as catalyst in toluene–H2O at room temperature.
  
  

• A Clomazone Immunoassay to Study the Environmental Fate of the Herbicide in Rice (Oryza sativa) Agriculture. (Completo, 2010)

  MATHO, C. , CANTOU, G. , SANBORN, J. , LAST, JEROLD , HAMMOCK, B. , ROEL, A. , GONZALEZ, D. , GONZALEZ-SAPIENZA, G.
  Journal of Agricultural and Food Chemistry, v.: 58 7 , p.:4367 - 4371, 2010
  Areas de conocimiento:
  Ciencias Naturales y Exactas / Ciencias Químicas / Química Analítica /
  Medio de divulgación: Internet
  Lugar de publicación: USA
  ISSN: 00218561
  E-ISSN: 15205118
  http://pubs.acs.org/doi/full/10.1021/jf9043259
  Abstract: The environmental impact of rice agriculture is poorly studied in developing countries, mainly due to limitations of the analytical capacity. Here, we report the development of a clomazone enzyme-linked immunosorbent assay as a fast and cost-effective tool to monitor the dissipation of this herbicide along the harvest. Antibodies were prepared using different strategies of hapten conjugation, and the best hapten/antibody pair was selected. It proved to be a reliable tool to measure the herbicide in the 2.0−20 ng/mL range in field samples, with excellent correlation with high-performance liquid chromatography results. The assay was used to study the dissipation of the herbicide in the floodwater of experimental rice paddies in Uruguay. Large differences in the residual amounts of herbicide were observed depending on the flooding practices. Because of its robustness and simplicity, the assay may be useful to delineate and monitor management practices that can contribute to minimizing the release of the herbicide in the environment.
  
  

• Enantiospecific synthesis and insect feeding activity of sulfur containing cyclitols. (Completo, 2009)

  BELLOMO, A. , CAMARANO, S. , ROSSINI, C. , GONZALEZ, D.
  Carbohydrate Research, v.: 343 1 , p.:44 - 51, 2009
  Areas de conocimiento:
  Ciencias Naturales y Exactas / Ciencias Químicas / Química Orgánica /
  Medio de divulgación: Internet
  E-ISSN: 00086215
  http://dx.doi.org/10.1016/j.carres.2008.09.026
  Abstract: The first syntheses of two deoxythiocyanocyclitols (4-deoxy-4-thiocyano-l-chiro-inositol and deoxythiocyanoconduritol F) and two deoxysulfonylcyclitol acetals are reported by a chemoenzymatic enantioselective route. The compounds were prepared by a sequence of enzymatic and ruthenium-catalyzed dihydroxylations, and the results were studied regarding reaction conditions and co-catalyst for different derivatives. The new compounds were included in a minilibrary of deoxygenated cyclitols and evaluated for their capacity to influence the feeding behavior of Epilachna paenulata (Coleoptera: Coccinellidae), a common pest of the Curcubitaceae crops.
  
  

• Chemoenzymatic synthesis of glycosyl-deoxyinositol derivatives. First example of a fagopyritol analog containing an aminoinositol unit. (Completo, 2009)

  BELLOMO, A. , BONILLA, J. B. , LOPEZ-PRADOS, J. , MARTIN-LOMAS, M. , GONZALEZ, D.
  Tetrahedron Asymmetry, v.: 20 17 , p.:2061 - 2064, 2009
  Areas de conocimiento:
  Ciencias Naturales y Exactas / Ciencias Químicas / Química Orgánica /
  Medio de divulgación: Internet
  Lugar de publicación: USA
  E-ISSN: 09574166
  http://dx.doi.org/10.1016/j.tetasy.2009.08.011
  Abstract: The first synthesis of two fagopyritol β-analogues (β-d-galactopyranosyl-(1′→1)-conduramine F-4 and β-d-galactopyranosyl-(1′→3)-4-aminodeoxy-l-chiro-inosito l) has been accomplished by a chemoenzymatic route in satisfactory yields. The key step of the synthesis is the TMSOTf-promoted glycosylation reaction of a deoxyconduritol derivative. The methodology is amenable to scale-up and expandable to the preparation of other pseudofagopyritols.
  
  

• Novel Deoxy-selenylconduritols: Chemoenzymatic Synthesis and Biological Evaluation. (Completo, 2009)

  BELLOMO, A. , BERTUCCI, A. , STEFANI, H. A. , VAZQUEZ, A. , GONZALEZ, D.
  Tetrahedron Letters, v.: 20 23 , p.:2673 - 2676, 2009
  Areas de conocimiento:
  Ciencias Naturales y Exactas / Ciencias Químicas / Química Orgánica /
  Medio de divulgación: Internet
  E-ISSN: 00404039
  http://dx.doi.org/10.1016/j.tetasy.2009.11.004
  Abstract: The first synthesis of two selenyldeoxycyclitols (4-Bromo-phenylselenyl conduritol F and Phenylselenylconduritol F) is reported by a chemoenzymatic enantioselective route. The key step of the synthesis is the selenolysis of a vinyl epoxide. The new compounds were evaluated for their capacity to inhibit the growth of different microorganisms using a modification of the agar diffusion technique with thin layer chromatography plates as support.
  
  

• Consecutive Biocatalysis-Palladium Catalysis II: Synthesis of Conduritol-Alkyne Conjugates. (Completo, 2009)

  BELLOMO, A. , WEBER M. , GONZALEZ, D. , STEFANI, H. A.
  Catalysis Communications, v.: 10 p.:1647 - 1650, 2009
  Areas de conocimiento:
  Ciencias Naturales y Exactas / Ciencias Químicas / Química Orgánica /
  Medio de divulgación: Internet
  ISSN: 15667367
  http://dx.doi.org/10.1016/j.catcom.2009.05.001
  Abstract: The palladium-catalyzed cross-coupling reaction of potassium alkynyltrifluoroborates with a chemoenzymatically derived deoxyconduritol is described. Six new compounds were synthesized in moderate to good yields. The alkynyl cross-coupling reaction can be effected using 10 mol% of Pd(PPh3)4 as catalyst in toluene-H2O in the presence of Cs2CO3 as the inorganic base.
  
  

• First record of L-quebrachitol in Allophylus edulis (Sapindaceae) (Completo, 2008)

  DIAZ, M. , GONZALEZ, A. , CASTRO-GAMBOA, I. , GONZALEZ, D. , ROSSINI, C.
  Carbohydrate Research, v.: 343 p.:2699 - 2700, 2008
  Areas de conocimiento:
  Ciencias Naturales y Exactas / Ciencias Químicas / Química Orgánica /
  Medio de divulgación: Internet
  E-ISSN: 00086215
  http://dx.doi:10.1016/j.carres.2008.07.014
  Abstract Allophylus edulis, commonly called Chal chal, is a member of the Sapindaceae occurring in the Uruguayan and Brazilian native flora. During the phytochemical analysis of two Chal chal specimens from two well-differentiated geographical zones (Assis, S o Paulo, Brazil, and Santa Luc a, Canelones, Uruguay), considerable amounts of L-quebrachitol were isolated from both samples. The isolation was carried out from the ethanolic twig extracts obtained by maceration of both vegetal samples. White easily distinguishable crystals were mechanically separated, washed, and characterized by 1D and 2D NMR experiments and by MS data. Such techniques confirmed that the crystals isolated from sources collected in both countries resulted in the same compound, l-quebrachitol, a natural product not previously reported for this species and one that has been investigated as a sugar substitute for diabetics. Worthy of note, the content of L-quebrachitol in A. edulis may be the chemical basis to explain its ethnobotanical uses, since infusions of this plant are used to treat diabetes in the practice of local traditional medicine.
  
  

• Synthesis of unnatural cyclitols via combined enzymatic-palladium catalysis approach. (Completo, 2008)

  BELLOMO, A. , GONZALEZ, D. , STEFANI, H. A.
  Journal of Organometallic Chemistry, v.: 693 p.:1136 - 1142, 2008
  Areas de conocimiento:
  Ciencias Naturales y Exactas / Ciencias Químicas / Química Orgánica /
  Medio de divulgación: Internet
  E-ISSN: 0022328X
  http://dx.doi.org/10.1016/j.jorganchem.2008.01.006
  Abstract The Suzuki–Miyaura cross-coupling reaction of a hydroxylated vinyl bromide obtained by a chemoenzymatic approach with a diverse range of potassium organotrifluoroborates has been accomplished catalyzed by Pd(PPh3)4 in satisfactory yields. A variety of functional groups are tolerated in the nucleophilic partner.
  
  

• Are endophytic microorganisms involved in the stereoselective reduction of ketones by Daucus carota root? (Completo, 2007)

  RODRIGUEZ BONNECARRÈRE, P. , BARTON, M. , ALDABALDE, V. , ONETTO, S. , PANIZZA, P. , MENENDEZ, P. , GONZALEZ, D. , RODRÍGUEZ GIORDANO, S.
  Journal of Molecular Catalysis B Enzymatic, v.: 49 p.:8 - 11, 2007
  Areas de conocimiento:
  Ciencias Naturales y Exactas / Ciencias Químicas / Química Orgánica / Biocatalisis
  Medio de divulgación: Internet
  ISSN: 13811177
  http://dx.doi.org/10.1016/j.molcatb.2007.06.011
  Abstract Four strains of endophytic microorganisms isolated from carrot root were able to carry out the reduction of the carbonyl group with diverse degree of enantio-, and diasteroselectivity. Furthermore, biotransformation in the presence of bacterial inhibitor affects the stereochemical outcome of the reaction, and the concomitant addition of a yeast inhibitor results in a large decrease in the conversion percentage. These results indicate that endophytic microorganisms might be involved in the enantioselective reduction of ketones and ketoesters with fresh carrot root pieces.
  
  

• Diasterodivergent synthesis of optically pure vinyl episulphides and hydroxy thiocyanates from a bacterial metabolite. (Completo, 2007)Trabajo relevante

  BELLOMO, A. , GONZALEZ, D.
  Tetrahedron Letters, v.: 48 p.:3047 - 3051, 2007
  Areas de conocimiento:
  Ciencias Naturales y Exactas / Ciencias Químicas / Química Orgánica /
  Medio de divulgación: Internet
  E-ISSN: 00404039
  http://dx.doi.org/10.1016/j.tetlet.2007.02.113
  Abstract Diasterodivergent episulfides were chemoenzymatically derived from bromobenzene by sequential toluene dioxygenase dihydroxylation, followed by chemical epoxidation and thiolysis. The epoxide ring-opening by thiocyanate ion under literature conditions rendered the corresponding hydroxy thiocyanates and not the thiiranes as usually observed. Ring closing under carefully optimized conditions allowed the preparation of optically pure thiiranes that are key precursors for the preparation of thioconduritols and pseudodisaccharides.
  
  

• Enzymatic synthesis of chiral heteroaryl alcohols using plant fragments as the only biocatalyst and reducing agent. (Completo, 2007)

  ALDABALDE, V. , ARCIA, P. , GONZALEZ, A. , GONZALEZ, D.
  Green Chemistry Letters and Reviews, v.: 1 1 , p.:25 - 30, 2007
  Areas de conocimiento:
  Ciencias Naturales y Exactas / Ciencias Químicas / Química Orgánica / Biocatalisis
  Medio de divulgación: Internet
  ISSN: 17518253
  E-ISSN: 17517192
  DOI: 10.1080/17518250701756983
  http://www.tandfonline.com/doi/abs/10.1080/17518250701756983#.Uy-lM_ldV2A
  Abstract: The enzymatic reduction of prochiral heterocyclic ketones by carrot (Daucus carota) root in water afforded the corresponding S-alcohols in accordance with the Prelog's rule. The reaction was performed under various conditions in order to optimize the procedure of bioreduction regarding reaction time, yield, and optimal mass of carrot. The optimized procedure was used to test the ability of other plants to carry out the reaction. In the latter experiment, it was observed that, with regard to stereospecificity, most vegetables tested were poorer reducing agents compared to D. carota.
  
  

• Chemoenzymatic synthesis and biological evaluation of (-)-conduramine C-4. (Completo, 2007)

  BELLOMO, A. , GIACOMINI, C. , BRENA, B. , SEOANE, G. , GONZALEZ, D.
  Synthetic Communications, v.: 37 p.:3509 - 3518, 2007
  Areas de conocimiento:
  Ciencias Naturales y Exactas / Ciencias Químicas / Química Orgánica /
  Medio de divulgación: Internet
  ISSN: 00397911
  E-ISSN: 15322432
  http:/dx.doi.org/10.1080/00397910701555725
  Abstract Previously unreported (−)‐conduramine C‐4 was synthesized in six steps from a bacterial bromobenzene metabolite in 23% overall yield. The chemoenzymatic route involved toluene dioxygenase dihydroxylation, β‐epoxidation, epoxide ring‐opening, Staudinger reduction, radical debromination, and Amberlite‐ catalyzed hydrolysis. (−)‐Conduramine C‐4 and other related compounds synthesised were assayed for galactosidase‐activity inhibition against β‐D‐galactoside galactohidrolase isolated from Aspergillus oryzae.
  
  

• Catalytic Thiolysis of Chemoenzymatically Derived Vinylepoxides. Efficient Synthesis of Homochiral Phenylthioconduritol F. (Completo, 2006)

  BELLOMO, A. , GONZALEZ, D.
  Tetrahedron Asymmetry, v.: 17 p.:474 - 478, 2006
  Areas de conocimiento:
  Ciencias Naturales y Exactas / Ciencias Químicas / Química Orgánica /
  Medio de divulgación: Internet
  E-ISSN: 09574166
  http://dx.doi.org/10.1016/j.tetasy.2006.01.024
  Abstract The chemoenzymatic synthesis of enantiomerically pure phenylthioconduritol F obtained in 44% overall yield is described. The key step of the synthesis is the Yb(III) thiolysis of a vinyl epoxide, which was studied in depth. The methodology is amenable to scale up and expandable to the preparation of other thiocyclitols.
  
  

• Creacion de un sistema de aprendizaje programado (sap) fortalecido con grupos de interaccion estudiante/docente. (Completo, 2006)

  BELLOMO, A. , BROVETTO, M. , COMAS, H. , ONETTO, S. , ROLDOS, V. , RODRIGUEZ-AYAN, M. N. , GONZALEZ, D. , PANDOLFI, E.
  Anuario Latinoamericano de Educación Química, v.: 21 p.:139 - 142, 2006
  Areas de conocimiento:
  Ciencias Naturales y Exactas / Ciencias Químicas / Química Orgánica / Educacion
  Medio de divulgación: Papel
  Lugar de publicación: San Luis
  ISSN: 0328087X
  Abstract: We herein describe a Programmed Learning System (PLS or SAP in its Spanish acronym) for the Organic Chemistry 102 course of Facultad de Química (UdelaR). The system is based on a series of interactive problem exercises offered in a web site. The web-based problems are complemented with periodical face-to-face meetings among tutors and students gathered in small groups. The tutor worked with the students along the semester to clear out doubts on the problems and walk forward in a deeper understanding of the subject of study. Moreover, the student-teacher interaction operated as feedback to optimize the PLS and allowed its expansion to other organic chemistry courses.
  
  

• Enantioselective Reduction by Crude Plant Parts: Reduction of Benzofuran-2-yl methyl ketone with Carrot (Daucus carota) Bits. (Completo, 2006)

  RAVIA, S. , GAMENARA, D. , SCHAPIRO, V. , BELLOMO, A. , ADUM, J. , SEOANE, G. , GONZALEZ, D.
  Journal of Chemical Education, v.: 83 p.:1049 - 1051, 2006
  Areas de conocimiento:
  Ciencias Naturales y Exactas / Ciencias Químicas / Química Orgánica / Biocatalisis
  Ciencias Naturales y Exactas / Ciencias Químicas / Química Orgánica / Educacion
  Medio de divulgación: Internet
  ISSN: 00219584
  E-ISSN: 19381328
  http:/dx.doi.org/10.1021/ed083p1049
  Abstract: The use of biocatalysis and biotransformations are important tools in green chemistry. The enantioselective reduction of a ketone by crude plant parts, using carrot (Daucus carota) as the reducing agent is presented. The experiment introduces an example of a green chemistry procedure that can be tailored to fit in a regular laboratory session. Among other concepts, the experiment teaches chromatographic separation on the microscale level.
  
  

• Concise Chemoenzymatic Synthesis of epi-Inositol (Completo, 2004)

  VITELIO, C. , BELLOMO, A. , BROVETTO, M. , VITELIO, C. , GONZALEZ, D.
  Carbohydrate Research, v.: 339 10 , p.:1773 - 1778, 2004
  Areas de conocimiento:
  Ciencias Naturales y Exactas / Ciencias Químicas / Química Orgánica /
  Medio de divulgación: Internet
  E-ISSN: 00086215
  http://dx.doi.org/10.1016/j.carres.2004.04.011
  Abstract epi-Inositol was synthesized in six steps in 40% overall yield from a bacterial bromobenzene metabolite. The chemoenzymatic route involved toluene dioxygenase oxidation, substrate-directed catalytic osmylation, m-CPBA epoxidation, radical debromination, and Amberlite-catalized hydrolysis. The route described is amenable to scaleup and could allow access to cis-inositol, and deoxy derivatives of epi-inositol.
  
  

• Total Synthesis and Biological Evaluation of Amaryllidaceae Alkaloids: Narciclasine, ent-7-Deoxypancratistatin, 7-Deoxypancratistatin, and Truncated Derivatives. (Completo, 2002)

  HUDLICKY, T. , RINNER, U. , GONZALEZ, D. , AKGUN, H. , SCHILLING, S. , SIENGALEWICZ, P. , MARTINOT, T. , PETTIT, G. R.
  The Journal of Organic Chemistry, v.: 67 p.:8726 - 8743, 2002
  Areas de conocimiento:
  Ciencias Naturales y Exactas / Ciencias Químicas / Química Orgánica /
  Medio de divulgación: Internet
  ISSN: 00223263
  E-ISSN: 15206904
  http://pubs.acs.org/doi/abs/10.1021/jo020129m
  Abstract: Biocatalytic approaches have yielded efficient total syntheses of the major Amaryllidaceae alkaloids, all based on the key enzymatic dioxygenation of suitable aromatic precursors. This paper discusses the logic of general synthetic design for lycoricidine, narciclasine, pancratistatin, and 7-deoxypancratistatin. Experimental details are provided for the recently accomplished syntheses of narciclasine, ent-7-deoxypancratistatin, and 10b-epi-deoxypancratistatin via a new and selective opening of a cyclic sulfate over aziridines followed by aza-Payne rearrangement. The structural core of 7-deoxypancratistatin has also been degraded to a series of intermediates in which the amino inositol unit is cleaved and deoxygenated in a homologous fashion. These truncated derivatives and the compounds from the synthesis of the unnatural derivatives have been tested against six important human cancer cell lines in an effort to further develop the understanding of the mode of action for the most active congener in this group, pancratistatin. The results of the biological activity testing as well as experimental, spectral, and analytical data are provided in this manuscript for all relevant compounds.
  
  

• Enzymatic Dihydroxylation of Aromatics in Enantioselective Synthesis: Expanding Asymmetric Methodology. (Completo, 1999)Trabajo relevante

  HUDLICKY, T. , GONZALEZ, D. , GIBSON, D. T.
  Aldrichimica Acta, v.: 32 p.:35 - 62, 1999
  Areas de conocimiento:
  Ciencias Naturales y Exactas / Ciencias Químicas / Química Orgánica /
  Medio de divulgación: Internet
  E-ISSN: 00025100
  http://www.sigmaaldrich.com/etc/medialib/docs/Aldrich/Acta/al_acta32_2.Par.0001.File.tmp/al_acta32_2
  Description: A review on synthetic application of dioxygenases including data for 122 optically pure metabolites and all chemical modifications described until 1999.
  
  

• Electron transfer catalyzed 2+2 cycloreversion of benzene dimers (Completo, 1999)

  REDDY, G. D. , WIEST, O. , HUDLICKY, T. , SCHAPIRO, V. , GONZALEZ, D.
  The Journal of Organic Chemistry, v.: 64 8 , p.:2460 - 2463, 1999
  Areas de conocimiento:
  Ciencias Naturales y Exactas / Ciencias Químicas / Química Orgánica /
  Medio de divulgación: Papel
  ISSN: 00223263
  E-ISSN: 15206904
  DOI: 10.1021/jo982398b
  http://pubs.acs.org/doi/abs/10.1021/jo982398b
  Abstract: The catalysis of the [2 + 2] cycloreversion of the anti-o,o‘-benzene dimer 1 and the syn-o,o‘-naphthalene-benzene dimer 2 through thermal and photoinduced electron transfer is studied using experimental and computational methods. The reaction of the radical cations formed by electron transfer is at least 105 times faster than the thermal background reaction. It is demonstrated that the photoinduced electron transfer catalyzed reaction proceeds via an electron transfer sensitized pathway and that the observed inverse secondary deuterium isotope effect of 0.91 ± 0.02 on the reaction is due to the equilibrium isotope effect on the electron transfer step. The relevance of these findings on the mechanism of the electron transfer catalyzed [2 + 2] cycloreversion of the biologically important cis,syn-cyclobutane-thymine dimer is also discussed.
  
  

• A short chemoenzymatic synthesis of (+)-narciclasine (Completo, 1999)

  GONZALEZ, D. , MARTINOT, T. , HUDLICKY, T.
  Tetrahedron Letters, v.: 40 16 , p.:3077 - 3080, 1999
  Areas de conocimiento:
  Ciencias Naturales y Exactas / Ciencias Químicas / Química Orgánica /
  Medio de divulgación: Internet
  E-ISSN: 00404039
  http://dx.doi.org/10.1016/S0040-4039(99)00433-5
  Abstract: The title alkaloid has been synthesized in eight operations from dibromobenzene and o-vanillin, via enzymatic oxidation of the former compound, Suzuki coupling and aBischler-Napieralski type cyclization as the key transformations.
  
  

• Toward a practical synthesis of morphine. The first several generations of a radical cyclization approach (Completo, 1998)

  BUTORA, G. , HUDLICKY, T. , FEARNLEY, S. P. , STABILE, M. , GUM, A. , GONZALEZ, D.
  Synthesis, p.:665 - 681, 1998
  Areas de conocimiento:
  Ciencias Naturales y Exactas / Ciencias Químicas / Química Orgánica /
  Medio de divulgación: Papel
  ISSN: 00397881
  E-ISSN: 1437210X
  http://www.brocku.ca/mathematics-science/departments-and-centres/chemistry/faculty/Hudlicky/Synthesi
  Abstract: A radical cyclization approach to the complete skeleton of morphine was investigated in several iterations. The first attempt at a radical cascade via a Bergman-type intermediate derived from ene-diyne 10 failed during a model study in which 10-membered silicon-tethered ene-diyne 17 proved inert to Bergman cyclization conditions. A second model study involving ene-diyne 27, functionalized with an allyl group, underwent Claisen rearrangement to 32 in preference to a Bergman-type cyclization.
  
  

• New metabolites from the microbial oxidation of fluorinated aromatic compounds (Completo, 1998)

  HUDLICKY, T. , GONZALEZ, D. , ENDOMA, M. A. A. , STABILE, M. , DELUCA, M. , PARKER, D. , GIBSON, D. T. , RESNICK, S. , WHITED, G.
  Journal of Fluorine Chemistry, v.: 89 1 , p.:23 - 30, 1998
  Areas de conocimiento:
  Ciencias Naturales y Exactas / Ciencias Químicas / Química Orgánica /
  Medio de divulgación: Papel
  ISSN: 00221139
  http://www.sciencedirect.com/science/article/pii/S0022113998000815
  Abstract: m-Bromo-α,α,α-trifluorotoluene (1) and 1-bromo-2,3-difluorobenzene (4) were subjected to microbial oxidation by Pseudomonas putida strain 39/D and the corresponding Escherichia coli recombinant microorganism (strain JM 109(pDTG601)), which express toluene dioxygenase. The absolute stereochemistry of the major oxidation products have been determined as cis-(2R,3S)-5-bromo-2,3-dihydroxy-α,α,α-trifluoromethylcyclohexa-4,6-diene (2), and cis-(2S,3S)-1-bromo-5,6-difluoro-2,3-dihydroxy-4,6-diene (5). The regiochemistry of a minor metabolite has been established as cis-5-bromo-3,4-dihydroxy-α,α,α-trifluoromethylcyclohexa-1,5-diene (3).
  
  

• New metabolites from toluene dioxygenase dihydroxylation of oxygenated biphenyls (Completo, 1997)

  SCHAPIRO, V. , GONZALEZ, D. , SEOANE, G. , HUDLICKY, T.
  Tetrahedron Asymmetry, v.: 8 7 , p.:975 - 977, 1997
  Areas de conocimiento:
  Ciencias Naturales y Exactas / Ciencias Químicas / Química Orgánica /
  Medio de divulgación: Internet
  E-ISSN: 09574166
  http://www.sciencedirect.com/science/article/pii/S0957416697000591
  Abstract: Direct microbial oxidation of 2-methoxybiphenyl and 2,3-dimethoxybiphenyl by E. coli JM109 (pDTG601) furnished enantiomerically pure 3-(2-methoxyphenyl)-(1S,2R)-3,5-cyclohexadiene-1,2-diol (2) and 3-(2,3-dimethoxyphenyl)-(1S,2R)-3,5-cyclohexadiene-1,2-diol (3) respectively as the only reaction products.
  
  

• Chemoenzymatic synthesis of unnatural amino acids via modified claisen rearrangement of glycine enolates. Approach to morphine synthesis (Completo, 1997)

  GONZALEZ, D. , SEOANE, G. , SCHAPIRO, V. , HUDLICKY, T.
  The Journal of Organic Chemistry, v.: 62 5 , p.:1194 - 1195, 1997
  Areas de conocimiento:
  Ciencias Naturales y Exactas / Ciencias Químicas / Química Orgánica /
  Medio de divulgación: Internet
  ISSN: 00223263
  E-ISSN: 15206904
  http://pubs.acs.org/doi/full/10.1021/jo962315w
  Abstract: The Kasmaier-Claisen rearrangement was applied for the first time in the synthesis of chiral optically pure unnatural amino acids.
  
  

• A controlled stepwise oxidation of ethyl 2-oxothiazolidine-4- carboxylate to the corresponding 2-hydroxythiazole (Completo, 1995)

  SERRA, G. , GONZALEZ, D. , MANTA, E.
  Heterocycles, v.: 41 12 , p.:2701 - 2711, 1995
  Areas de conocimiento:
  Ciencias Naturales y Exactas / Ciencias Químicas / Química Orgánica /
  Medio de divulgación: Internet
  ISSN: 03855414
  DOI: 10.3987/COM-95-7137
  http://jglobal.jst.go.jp/public/20090422/200902161085259860
  Abstract: Methyl 2-hydroxythiazole-4-carboxylate was obtained via a controlled stepwise oxidative procedure from the corresponding 2-oxothiazolidine. A series of intermediates have been isolated and characterized, supporting the ionic and radical mechanisms already proposed in the literature.
  
  

Fabricacion de alcoholes quirales a escala de laboratorio (2006)

Fabricacion de bromociclohexanodiol opticamente puro a escala de 500 g (1999)

Fabricacion de D-chiro-inositol a escala de 10 g (1998)

Alternativas verdes para la fabricacion de menadiona (vitamina K) (2005)

Posgrado

• Biotransformaciones de glicerol por cepas inmovilizadas de Gluconobacter (2018 - 2020)

  Tesis de maestria
  Sector Educación Superior/Público / Universidad de la República / Facultad de Química , Uruguay
  Programa: Maestría en Química (UDELAR - PEDECIBA)
  Tipo de orientación: Asesor
  Nombre del orientado: Magdalena Ripoll
  País: Uruguay
  Director Académico. La Dra. Lorena Bentancor fue la tutora de Tesis.

• Nuevas herramientas biocatalíticas para la síntesis asimétrica: enoato reductasas, carbonilo reductasas, transaminasas y amonio liasas.

  Tesis de doctorado
  Sector Educación Superior/Público / Universidad de la República / Facultad de Química , Uruguay
  Tipo de orientación: Cotutor en pie de igualdad
  Nombre del orientado: Cesar Iglesias
  País: Uruguay
  Areas de conocimiento:
  Ciencias Naturales y Exactas / Ciencias Biológicas / Otros Tópicos Biológicos / Biocatálisis
  Co-tutor junto a la Dra. Sonia Rodriguez (Tutora ppal)

• Síntesis y evaluación biológica de análogos del antibiótico higromicina A.

  Tesis de doctorado
  Sector Educación Superior/Público / Universidad de la República / Facultad de Química , Uruguay
  Programa: Doctorado en Química
  Tipo de orientación: Tutor único o principal
  Nombre del orientado: Gonzalo Carrau
  País: Uruguay
  Areas de conocimiento:
  Ciencias Naturales y Exactas / Ciencias Químicas / Química Orgánica / Sintesis Organica

• Síntesis quimioenzimática de análogos del alcaloide antitumoral pancratistatina.

  Tesis de doctorado
  Sector Educación Superior/Público / Universidad de la República / Facultad de Química , Uruguay
  Programa: Doctorado en Química
  Tipo de orientación: Tutor único o principal
  Nombre del orientado: Victoria de la Sovera
  País: Uruguay
  Areas de conocimiento:
  Ciencias Naturales y Exactas / Ciencias Químicas / Química Orgánica / Sintesis Organica

• Aproximación a la síntesis de componentes de feromonas sexuales de lepidopteros.

  Tesis de maestria
  Sector Educación Superior/Público / Universidad de la República / Facultad de Química , Uruguay
  Programa: Maestria en Quimica
  Tipo de orientación: Cotutor en pie de igualdad
  Nombre del orientado: Paola Liberatti
  País: Uruguay
  Areas de conocimiento:
  Ciencias Naturales y Exactas / Ciencias Químicas / Química Orgánica / Sintesis Organica Quimica Ecologica
  Co-tutor junto con el Prof. Andres Gonzalez.

• Aislamiento y caracterización de microorganismos endofíticos para su empleo en reacciones biocatalíticas.

  Tesis de doctorado
  Sector Educación Superior/Público / Universidad de la República / Facultad de Química , Uruguay
  Programa: Doctorado en Química
  Tipo de orientación: Cotutor en pie de igualdad
  Nombre del orientado: Paula Rodriguez
  País: Uruguay
  Areas de conocimiento:
  Ciencias Naturales y Exactas / Ciencias Químicas / Química Orgánica / Biocatalisis
  Co-Tutor junto a la Dra. Sonia Rodriguez

• Introducción de conceptos de Química Verde en Educación Secundaria: ventajas y desafíos.

  Tesis de maestria
  Sector Educación Superior/Público / Universidad de la República / Facultad de Química , Uruguay
  Programa: Maestría en Química (orientación Educación en Química)
  Tipo de orientación: Cotutor en pie de igualdad
  Nombre del orientado: Pedro Casullo
  País: Uruguay
  Areas de conocimiento:
  Ciencias Naturales y Exactas / Ciencias Químicas / Química Orgánica / Quimica Verde
  Co-Tutor junto a la Dra. Pilar Menendez

• Estrategias para el análisis de fármacos en muestras biológicas y su aplicación en control de doping en deportes equinos.

  Tesis de maestria
  Sector Educación Superior/Público / Universidad de la República / Facultad de Química , Uruguay
  Programa: Maestría en Química (UDELAR-PEDECIBA)
  Tipo de orientación: Cotutor en pie de igualdad
  Nombre del orientado: Tania Possi
  País: Uruguay
  Areas de conocimiento:
  Ciencias Naturales y Exactas / Ciencias Químicas / Química Analítica / Espectrometría de masa
  Codirección junto a la Dra. Alejandra Rodriguez.

• Antifúngicos de la Flora Nativa Uruguaya.

  Tesis de doctorado
  Sector Educación Superior/Público / Universidad de la República / Facultad de Química , Uruguay
  Programa: Doctorado en Química
  Tipo de orientación: Cotutor en pie de igualdad
  Nombre del orientado: Ana Beatriz Bertucci
  País: Uruguay
  Areas de conocimiento:
  Ciencias Naturales y Exactas / Ciencias Químicas / Química Orgánica / Química de los productos naturales
  Co-Tutor con el Dr. Patrick Moyna a partir de 2011.

• Sintesis de conjugados de ciclitoles de potencial actividad biologica Trabajo relevante

  Tesis de doctorado
  Sector Educación Superior/Público / Universidad de la República / Facultad de Química , Uruguay
  Programa: Doctorado en Química
  Tipo de orientación: Tutor único o principal
  Nombre del orientado: Ana Bellomo
  País: Uruguay
  Areas de conocimiento:
  Ciencias Naturales y Exactas / Ciencias Químicas / Química Orgánica / Sintesis Organica

Grado

• Estudio de dos rutas complementarias para la síntesis de fluoxetina.

  Tesis/Monografía de grado
  Sector Educación Superior/Público / Universidad de la República / Facultad de Química , Uruguay
  Programa: Licenciatura en Química
  Tipo de orientación: Tutor único o principal
  Nombre del orientado: Juan Arciet
  País: Uruguay
  Palabras Clave: síntesis asimétrica Fluoxetina
  Areas de conocimiento:
  Ciencias Naturales y Exactas / Ciencias Químicas / Química Orgánica

• Reducción estereoselectiva de cetonas benzílicas mediante levaduras endofíticas y raíz de Daucus carota.

  Tesis/Monografía de grado
  Sector Educación Superior/Público / Universidad de la República / Facultad de Química , Uruguay
  Programa: Licenciatura en Química
  Tipo de orientación: Tutor único o principal
  Nombre del orientado: Victoria Schmidt-Liermann
  País: Uruguay
  Areas de conocimiento:
  Ciencias Naturales y Exactas / Ciencias Químicas / Química Orgánica / Biocatalisis

• Síntesis del residuo ciclitólico de higromicina A.

  Tesis/Monografía de grado
  Sector Educación Superior/Público / Universidad de la República / Facultad de Química , Uruguay
  Programa: Licenciatura en Química
  Tipo de orientación: Tutor único o principal
  Nombre del orientado: Gonzalo Carrau
  País: Uruguay
  Areas de conocimiento:
  Ciencias Naturales y Exactas / Ciencias Químicas / Química Orgánica / Sintesis Organica

• Practicantado de fin de Carrera - Plan 2000 (IMM - Laboratorio de Calidad Ambiental)

  Docente adscriptor/Practicantado
  Sector Educación Superior/Público / Universidad de la República / Facultad de Química , Uruguay
  Tipo de orientación: Asesor
  Nombre del orientado: Federico Andre
  País: Uruguay
  Areas de conocimiento:
  Ciencias Naturales y Exactas / Ciencias Químicas / Química Analítica / Quimica Ambiental

• Reduccion enzimatica de cetonas y aldehidos mediada por fragmentos de Daucus carota (zanahoria)

  Tesis/Monografía de grado
  Sector Educación Superior/Público / Universidad de la República / Facultad de Química , Uruguay
  Programa: Licenciatura en Química
  Tipo de orientación: Tutor único o principal
  Nombre del orientado: Virginia Aldabalde
  País: Uruguay
  Areas de conocimiento:
  Ciencias Naturales y Exactas / Ciencias Químicas / Química Orgánica / Biocatalisis

• Transesterificacion enzimatica de aceite de salvado de arroz utilizando la lipasa de Rizhomucor miehei.

  Tesis/Monografía de grado
  Sector Educación Superior/Público / Universidad de la República / Facultad de Química , Uruguay
  Programa: Licenciatura en Química
  Tipo de orientación: Tutor único o principal
  Nombre del orientado: Guillermo Arias
  País: Uruguay
  Areas de conocimiento:
  Ciencias Naturales y Exactas / Ciencias Químicas / Química Orgánica / Biocatalisis

• Analisis y proceso de fabricacion de menadiona.

  Docente adscriptor/Practicantado
  Sector Educación Superior/Público / Universidad de la República / Facultad de Química , Uruguay
  Tipo de orientación: Asesor
  Nombre del orientado: Jorge Adum
  País: Uruguay
  Areas de conocimiento:
  Ciencias Naturales y Exactas / Ciencias Químicas / Química Orgánica / quimica iondustrial
  Supervisior en FQ de la pasantia de fin de carrera realizada en la empresa Dirox SA.

Otras

• Síntesis enantioselectiva de inosaminas y derivados

  Iniciación a la investigación
  Sector Educación Superior/Público / Universidad de la República / Facultad de Química , Uruguay
  Tipo de orientación: Cotutor en pie de igualdad
  Nombre del orientado: Natalia Rodriguez
  País: Uruguay
  Palabras Clave: aminocyclitols inosamines
  Areas de conocimiento:
  Ciencias Naturales y Exactas / Ciencias Químicas / Química Orgánica / Sintesis Organica

• Síntesis enzimática de precursores de R- y S-fluoxetina.

  Iniciación a la investigación
  Sector Educación Superior/Público / Universidad de la República / Facultad de Química , Uruguay
  Tipo de orientación: Tutor único o principal
  Nombre del orientado: Camila Coronel
  País: Uruguay
  Areas de conocimiento:
  Ciencias Naturales y Exactas / Ciencias Químicas / Química Orgánica / Biocatalisis

• Sintesis quimioenzimatica del antibiotico aminoglucosido higromicina A.

  Iniciación a la investigación
  Sector Educación Superior/Público / Universidad de la República / Facultad de Química , Uruguay
  Tipo de orientación: Tutor único o principal
  Nombre del orientado: Gonzalo Carrau
  País: Uruguay
  Areas de conocimiento:
  Ciencias Naturales y Exactas / Ciencias Químicas / Química Orgánica / Sintesis Organica

• Sintesis quimioenzimatica de la feromona de ovoposicion de mosquitos del genero culex (5R, 6S)-6-acetoxi-5-hexadecanólido.

  Iniciación a la investigación
  Sector Educación Superior/Público / Universidad de la República / Facultad de Química , Uruguay
  Tipo de orientación: Tutor único o principal
  Nombre del orientado: Gabriel Arce
  País: Uruguay
  Areas de conocimiento:
  Ciencias Naturales y Exactas / Ciencias Químicas / Química Orgánica / Sintesis Organica

• Biotransformación de herbicidas para la síntesis de haptenos.

  Iniciación a la investigación
  Sector Educación Superior/Público / Universidad de la República / Facultad de Química , Uruguay
  Tipo de orientación: Tutor único o principal
  Nombre del orientado: Lucia Zeballos
  País: Uruguay
  Areas de conocimiento:
  Ciencias Naturales y Exactas / Ciencias Químicas / Química Orgánica / Biocatalisis

• Estudio de la reducción enzimática de 3,5-dioxocineol mediada por vegetales. (codirección con P. Menendez y S. Rodriguez)

  Otras tutorías/orientaciones
  Sector Educación Superior/Público / Universidad de la República / Facultad de Química , Uruguay
  Tipo de orientación: Tutor único o principal
  Nombre del orientado: Adrian Anzorena
  País: Uruguay
  Areas de conocimiento:
  Ciencias Naturales y Exactas / Ciencias Químicas / Química Orgánica / Biocatalisis
  Pasantia de un profesor de Quimica en la Udelar en el marco del programa "Acortando Distancias" de cooperacion ENTRE UdelaR, CODICEN, ANII y PEDECIBA.

• Sintesis quimioenzimatica de analogos del alcaloide antitumoral pancratistatina.

  Iniciación a la investigación
  Sector Educación Superior/Público / Universidad de la República / Facultad de Química , Uruguay
  Tipo de orientación: Tutor único o principal
  Nombre del orientado: Victoria de la Sovera
  País: Uruguay
  Areas de conocimiento:
  Ciencias Naturales y Exactas / Ciencias Químicas / Química Orgánica / Sintesis Organica
  Co-Tutor jnto a la Dra. Ana Bellomo

• Sintesis enzimatica de ciclohexadienodioles opticamente activos (codireccion con G. Seoane)

  Otras tutorías/orientaciones
  Sector Educación Superior/Público / / , Uruguay
  Tipo de orientación: Tutor único o principal
  Nombre del orientado: Sr. Miguel Verde
  País: Uruguay
  Areas de conocimiento:
  Ciencias Naturales y Exactas / Ciencias Químicas / Química Orgánica / Biocatalisis
  Pasantia de un estudiante de profesorado en quimica en la UdelaR. Colaboracion Pedeciba Unesco.

• Sintesis quimioenzimatica de epi-inositol

  Otras tutorías/orientaciones
  Sector Educación Superior/Público / Universidad de la República / Facultad de Química , Uruguay
  Tipo de orientación: Tutor único o principal
  Nombre del orientado: Ing. Cecilia Vitelio
  País: Uruguay
  Areas de conocimiento:
  Ciencias Naturales y Exactas / Ciencias Químicas / Química Orgánica / Sintesis Organica
  Estudiante de iniciación científica. De su trabajo resultó la primera síntesis quimioenzimática de epi-inositol.